Heritability of anterior chamber depth as an intermediate phenotype of angle-closure in Chinese: the Guangzhou Twin Eye Study.

@article{He2008HeritabilityOA,
  title={Heritability of anterior chamber depth as an intermediate phenotype of angle-closure in Chinese: the Guangzhou Twin Eye Study.},
  author={Mingguang He and Dandan Wang and Yingfeng Zheng and Jian Zhang and Qiu-xia Yin and Wenyong Huang and David A. Mackey and Paul J. Foster},
  journal={Investigative ophthalmology \& visual science},
  year={2008},
  volume={49 1},
  pages={
          81-6
        }
}
PURPOSE To assess the heritability of anterior chamber depth (ACD) and relative anterior chamber depth (ACD/axial length, rACD) in Chinese in a classic twin study. METHODS Twins aged 7 to 15 years living in two local districts were recruited from the Guangzhou Twin Registry. Anterior chamber depth and axial length were measured by partial coherence laser interferometry. Zygosity in all same-sex twin pairs was confirmed by genotyping with 16 polymorphic markers. The phenotypes of the right… 
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42 Citations
Highly Influential Citations
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Background Citations
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Methods Citations
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Results Citations
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42 Citations

Citation Type

Citation Type

Shared genetic determinant of axial length, anterior chamber depth, and angle opening distance: the Guangzhou Twin Eye Study.
TLDR
Analyses of Chinese children twin data suggest that shared genes are responsible for the significant phenotypic correlations found for AL ACD, and AOD.
Heritability of the iridotrabecular angle width measured by optical coherence tomography in Chinese children: the Guangzhou twin eye study.
TLDR
The variance in drainage angle width in Chinese children appears to be largely attributable to genetic effects, with a heritability of approximately 70%.
Distribution and heritability of iris thickness and pupil size in Chinese: the Guangzhou Twin Eye Study.
TLDR
Iris thickness is thinner in girls but is not associated with age in children, and the variation is largely attributable to additive genetic effects.
Contribution of genetic and environmental effects on lens thickness: the Guangzhou Twin Eye study.
TLDR
It is confirmed that the LT in young healthy subjects may be mainly affected by additive genetic factors, and high heritability remains even when the data are corrected for the influence of AL with the use of rLT.
Distribution and heritability of peripheral eye length in Chinese children and adolescents: the Guangzhou Twin Eye Study.
TLDR
Additive genetic effects had a substantial influence on phenotypic variation in PEL and RPEL, suggesting genetic rather than environmental factors play a major role in determining eye shape.
Shared genetic determinants of axial length and height in children: the Guangzhou twin eye study.
TLDR
Covariance of AL and height is largely attributable to shared genes, which is a key determinant of myopia, and further work is needed to confirm gene sharing between myopia and stature.
Genetic Covariance Between Central Corneal Thickness and Anterior Chamber Volume: A Hungarian Twin Study
TLDR
The findings support the high heritability of ACV and central corneal thickness, and a strong genetic covariance between them, which underscores the importance of identification of the specific genetic factors and the family risk-based screening of disorders related to these variables.
Heritability of Anterior Chamber Indices in Rural Population
TLDR
The high heritability of the anterior chamber angle points to a high correlation between this phenotype and genetic factors and further genetic and molecular investigations are suggested to find the related genes and understand the etiology of glaucoma.
The heritability and sibling risk of angle closure in Asians.
Genotype-ocular biometry correlation analysis of eight primary angle closure glaucoma susceptibility loci in a cohort from Northern China
TLDR
The SNP rs3753841 in COL11A1, rs1258267 in CHAT and rs736893 in GLIS3 are associated with PACG in northern Chinese people, and the association of genetic markers manifests a tendency of ethnic diversity.
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