Heritability estimation of sex-specific effects on human quantitative traits.

  title={Heritability estimation of sex-specific effects on human quantitative traits.},
  author={Lin Pan and Carole Ober and Mark Abney},
  journal={Genetic epidemiology},
  volume={31 4},
Recent studies have suggested that sex-specific genetic architecture could be because of the effects of autosomal genes that are differentially expressed in males and females. Yet, few studies have explored the effects of X-linked genes on sex-specific genetic architecture. In this study, we extended the variance component, maximum likelihood method to evaluate the relative contributions of sex-specific effects on both autosomes and the X chromosome to estimates of heritability of 20… CONTINUE READING
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A new look at the statistical model identification

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