Heritability estimates and linkage analysis of 23 short tandem repeat loci on chromosomes 2, 11, and 12 in an endemic osteochondropathy in China.

@article{Shi2010HeritabilityEA,
  title={Heritability estimates and linkage analysis of 23 short tandem repeat loci on chromosomes 2, 11, and 12 in an endemic osteochondropathy in China.},
  author={Xingmin Shi and Xiuqing Guo and An L Lv and Lixia Kang and Yu Liang Zhou and Yan-zhao Zhang and Xiao M Wu and Yendluri Durga Bai},
  journal={Scandinavian journal of rheumatology},
  year={2010},
  volume={39 3},
  pages={259-65}
}
OBJECTIVE To estimate the heritability of Kashin-Beck disease (KBD) in first-degree relatives and to identify chromosome regions likely to contain susceptibility loci for KBD. METHODS A total of 331 probands with confirmed KBD in their pedigrees were selected from 9331 residents in 17 KBD villages of Linyou county, northwestern China. The heritability (h(2)) in first-degree relatives was estimated by using Falconer's formula. The segregation ratio was calculated by the Li-Mantel-Gart method… CONTINUE READING
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