Heritability, weak effects, and rare variants in genomewide association studies.

In less than 5 years, genomewide association studies (GWASs) have completely changed the landscape of human genetic research. Our increasing knowledge of the human genome sequence and its variation (http:// hapmap.ncbi.nlm.nih.gov/) and technological advances in the design of genotyping microarrays have been instrumental in this evolution; however, an… CONTINUE READING