Heregulin-induced epigenetic regulation of the utrophin-A promoter.

  title={Heregulin-induced epigenetic regulation of the utrophin-A promoter.},
  author={Utpal Basu and Mads Gyrd-Hansen and Santhosh M. Baby and Olga Lozynska and Thomas O. B. Krag and Claus J Jensen and Morten Fr{\"o}din and Tejvir S Khurana},
  journal={FEBS letters},
  volume={581 22},
Utrophin is the autosomal homolog of dystrophin, the product of the Duchenne's muscular dystrophy (DMD) locus. Utrophin is of therapeutic interest since its over-expression can compensate dystrophin's absence. Utrophin is enriched at neuromuscular junctions due to heregulin-mediated utrophin-A promoter activation. We demonstrate that heregulin activated… CONTINUE READING