Heregulin-dependent translocation and hyperphosphorylation of ErbB-2


Previous data have shown that in several tumor cells lines the addition of heregulin results in the translocation of ErbB-4 to a detergent-insoluble membrane fraction where it is hypertyrosine phosphorylated. The data herein demonstrate that heregulin or betacellulin, but not EGF, promotes the rapid translocation of ErbB-2, the heterodimerization partner… (More)
DOI: 10.1038/sj.onc.1204517


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