Heregulin ameliorates the dystrophic phenotype in mdx mice.

  title={Heregulin ameliorates the dystrophic phenotype in mdx mice.},
  author={Thomas O. B. Krag and Sasha Bogdanovich and Claus J Jensen and M Dominik Fischer and Jacob A Hansen-Schwartz and Elisabeth H. Javazon and Alan W. Flake and Lars Edvinsson and Tejvir S Khurana},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={101 38},
Duchenne's muscular dystrophy (DMD) is a fatal neuromuscular disease caused by absence of dystrophin. Utrophin is a chromosome 6-encoded dystrophin-related protein (DRP), sharing functional motifs with dystrophin. Utrophin's ability to compensate for dystrophin during development and when transgenically overexpressed has provided an important impetus for identifying activators of utrophin expression. The utrophin promoter A is transcriptionally regulated in part by heregulin-mediated… CONTINUE READING


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