Heredity and cortisol regulation in bilateral macronodular adrenal hyperplasia.

@article{Lacroix2013HeredityAC,
  title={Heredity and cortisol regulation in bilateral macronodular adrenal hyperplasia.},
  author={Andr{\'e} Lacroix},
  journal={The New England journal of medicine},
  year={2013},
  volume={369 22},
  pages={2147-9}
}
Cushing’s syndrome is a challenging disease in which excess cortisol is secondary to diverse tumors with complex molecular mechanisms. The syndrome has been categorized as corticotropindependent or corticotropin-independent. Approximately 20% of cases — mainly cortisol-secreting unilateral adenomas or carcinomas — are considered corticotropin-independent. Cushing’s syndrome rarely (in <2% of cases) results from primary bilateral nodular hyperplasia (either corticotropin-independent macronodular… CONTINUE READING

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