Hereditary spastic paraplegia.

  title={Hereditary spastic paraplegia.},
  author={John K. Fink},
  journal={Current neurology and neuroscience reports},
  volume={6 1},
  • John K. Fink
  • Published 2006 in Current neurology and neuroscience reports
The hereditary spastic paraplegias (HSPs) comprise a large group of inherited neurologic disorders. HSP is classified according to the mode of inheritance, the HSP locus when known, and whether the spastic paraplegia syndrome occurs alone or is accompanied by additional neurologic or systemic abnormalities. Analysis of 11 recently discovered HSP genes provides insight into HSP pathogenesis. Hereditary spastic paraplegia is a clinical diagnosis for which laboratory confirmation is sometimes… CONTINUE READING
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