Hereditary spastic paraplegia: Clinicogenetic lessons from 608 patients

@article{Schle2016HereditarySP,
  title={Hereditary spastic paraplegia: Clinicogenetic lessons from 608 patients},
  author={Rebecca Sch{\"u}le and Sarah Wiethoff and Peter Martus and Kathrin N. Karle and Susanne Otto and Stephan Klebe and Sven Klimpe and Constanze Gallenm{\"u}ller and Delia Kurzwelly and Dorothea Henkel and Florian Rimmele and Henning Stolze and Zacharias Kohl and Jan Kassubek and Thomas Klockgether and Stefan Vielhaber and Christoph Kamm and Thomas Klopstock and Peter Bauer and Stephan Z{\"u}chner and Inga Liepelt-Scarfone and Ludger Sch{\"o}ls},
  journal={Annals of Neurology},
  year={2016},
  volume={79}
}
OBJECTIVE Hereditary spastic paraplegias (HSPs) are genetically driven disorders with the hallmark of progressive spastic gait disturbance. [] Key MethodMETHODS We recruited 608 HSP cases from 519 families of mostly German origin. Clinical severity was assessed by the Spastic Paraplegia Rating Scale. Complicating symptoms were recorded by a standardized inventory. RESULTS Family history indicated dominant (43%), recessive (10%), and simplex (47%) disease.
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TLDR
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TLDR
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