Hereditary protein S deficiency: clinical manifestations.

  title={Hereditary protein S deficiency: clinical manifestations.},
  author={L Engesser and Andr{\'e} W. Broekmans and Ernest Bri{\"e}t and Emile J P Brommer and Rogier M. Bertina},
  journal={Annals of internal medicine},
  volume={106 5},
To analyze the clinical manifestations of protein S deficiency, we evaluated 136 members of 12 families with the disorder. Seventy-one persons were found to be heterozygous for protein S deficiency, which is inherited as an autosomal dominant trait. Venous thrombotic events occurred in 39 patients (55%) and were recurrent in 77%. Most symptomatic patients had various combinations of deep venous thrombosis (74%), superficial thrombophlebitis (72%), and pulmonary embolism (38%), either in… CONTINUE READING
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