Hereditary polyneuropathy in the Alaskan Malamute.

@article{Rentmeister2012HereditaryPI,
  title={Hereditary polyneuropathy in the Alaskan Malamute.},
  author={Kai Rentmeister and Thomas Bilzer and S. Li Petri and G Schanen and Michael Fehr and Ottmar Distl and Andrea Tipold},
  journal={Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere},
  year={2012},
  volume={40 1},
  pages={
          26-34
        }
}
OBJECTIVE To prove the hypothesis that a polyneuropathy in Alaskan Malamutes has a genetic background. [...] Key Method Neurological examination, electrodiagnosis as well as muscle and nerve biopsies could be performed in 10 dogs. Information about the disease status of the other 121 Alaskan Malamutes were supplied by referring veterinarians, breeders and owners.Expand
Hereditäre Polyneuropathie beim Alaskan Malamute
TLDR
It is demonstrated that polyneuropathy in Alaskan Malamutes is a hereditary disease with variable phenotypic expression ranging from severely affected to subclinical forms, which has to be considered in future gene analysis studies. Expand
Re-emergence of hereditary polyneuropathy in Scandinavian Alaskan malamute dogs—old enemy or new entity? A case series
TLDR
A well-documented example of the silent transmission of recessive disease-causing alleles through many generations is provided, demonstrated by the re-emergence of a phenotypically and genetically uniform entity in the Scandinavian Alaskan malamute population. Expand
Juvenile‐onset polyneuropathy in American Staffordshire Terriers
TLDR
Juvenile polyneuropathy, associated with laryngeal paralysis, is a newly described entity in American Staffordshire Terriers, and results from degenerative neuropathy. Expand
A Gly98Val Mutation in the N-Myc Downstream Regulated Gene 1 (NDRG1) in Alaskan Malamutes with Polyneuropathy
TLDR
It is concluded that the G>T substitution is most likely the mutation that causes polyneuropathy in Alaskan Malamutes and selection against this mutation can now be used to eliminate the disease in Al Alaska Malamute. Expand
Immunohistochemical analysis of canine and feline muscle disorders using formalin-fixed, paraffin-embedded tissues
TLDR
The immunohistochemical method described herein appears to be useful for discriminating neurogenic and myogenic disorders in formalin-fixed, paraffin-embedded muscle tissue of dogs and cats. Expand

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