Hereditary polioencephalomyelopathy of the Australian Cattle Dog

@article{Brenner1997HereditaryPO,
  title={Hereditary polioencephalomyelopathy of the Australian Cattle Dog},
  author={O. Brenner and Alexander de Lahunta and Brian A. Summers and John F. Cummings and Barry J. Cooper and Beth A. Valentine and Jerold S. Bell},
  journal={Acta Neuropathologica},
  year={1997},
  volume={94},
  pages={54-66}
}
Abstract A vacuolar degeneration affecting primarily the gray matter in the central nervous system (CNS) of young Australian Cattle Dogs is described. An initial presentation of seizures was followed by a progressive spastic tetraparesis. Grossly evident bilateral and symmetrical foci of malacia were in the nuclei of the cerebellum and brain stem and the gray matter of the spinal cord. Microscopically, vacuolation of glial cells, dilation of the myelin sheaths and reactive astrocytosis… Expand
A novel spongiform degeneration of the grey matter in the brain of a kitten.
TLDR
The age of the animal and histological changes suggested a novel, possibly congenital, spongiform degeneration of the brain and cervical spinal cord of a young female domestic short-hair cat. Expand
Alaskan Husky encephalopathy – a canine neurodegenerative disorder resembling subacute necrotizing encephalomyelopathy (Leigh syndrome)
TLDR
The gross and histopathological findings in the brain and spinal cord of five Alaskan Husky dogs with a novel incapacitating and ultimately fatal familial and presumed hereditary neurodegenerative disorder are described and neuropathological findings resemble Leigh’s disease/subacute necrotizing encephalomyelopathy of man. Expand
Spongy degeneration with cerebellar ataxia in Malinois puppies: a hereditary autosomal recessive disorder?
TLDR
Malinois suffer from a hereditary spongiform degeneration that predominates in the cerebellum and causes an early onset of clinical signs with unfavorable prognosis, and pedigree data and segregation frequency support an autosomal recessive hereditary disorder. Expand
Subacute necrotising encephalopathy in an Alaskan husky.
TLDR
A 29-month-old female Alaskan husky was presented recumbent, tetraparetic and in a state of dementia, with blindness and cranial nerve deficits, and a tentative diagnosis of a mitochondrial encephalopathy was made. Expand
A multifocal symmetrical necrotising encephalomyelopathy in Angus calves.
TLDR
Angus calves may develop a multifocal symmetrical necrotising encephalomyelopathy that is characterised by spongiosis of the neuropile, vascular hyperplasia, infiltration of gitter cells, spheroid formation and delayed degeneration of neurones. Expand
Severe necrotizing encephalitis in a Yorkshire terrier: topographic and immunohistochemical study.
TLDR
The lympho-histiocytic inflammation suggests a T-cell-mediated and a delayed-type immune reaction as a possible pathogenic mechanism for this brain disorder. Expand
Degenerative Encephalopathy in Nova Scotia Duck Tolling Retrievers Presenting with a Rapid Eye Movement Sleep Behavior Disorder
TLDR
A degenerative encephalopathy was identified in young adult NSDTRs consistent with a hereditary disease, and the prognosis is guarded due to the progressive nature of the disease, which is minimally responsive to empirical treatment. Expand
A Novel Idiopathic Superficial Neocortical Degeneration and Atrophy in Young Adult Dogs
TLDR
A diffuse, chronic, superficial neocortical degeneration that resulted in atrophy was detected in five 1 to 2-year-old-dogs, presenting neurologic signs included ataxia, dysphagia, blindness, and mentation changes, which suggests that this is a novel degenerative canine cerebral disease. Expand
Selective symmetrical necrotizing encephalopathy secondary to primary mitochondrial disorder in a cat
TLDR
Imaging and neuropathological findings were consistent with selective symmetrical necrotizing encephalopathy, for which genetic investigations support mitochondrial pathogenesis. Expand
Severe subacute necrotizing encephalopathy (Leigh-like syndrome) in American Staffordshire bull terrier dogs.
TLDR
Histopathology in all cases showed a bilaterally symmetrical necrotizing encephalopathy, with malacia of the neuropil centred on the vestibular and olivary nuclei of the brainstem, in American Staffordshire bull terrier dogs, the first documentation of a heritable rapidly progressive lethal necrotized encephalopathicopathy consistent with Leigh-like syndrome. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 31 REFERENCES
Spongy Degeneration of the Central Nervous System in Two Canine Littermates
TLDR
Clinical, histological, and ultrastructural findings resembled those reported for the juvenile form of Canavan's disease (van Bogaert and Bertrand type) in children. Expand
Ataxia/paresis syndrome of sheep in West Africa associated with bilateral multifocal cerebrospinal poliomalacia
TLDR
Between 1976 and 1981 a specific neurological disorder of sheep was observed in Ghana, and was characterised clinically by a brief period of ataxia, followed by paresis prostration and death in four to five days. Expand
Intracerebral distribution of mitochondrial abnormalities in 21 cases of infantile spongy dystrophy
TLDR
The results substantiate the classification of Leigh's disease as primary mitochondrial encephalopathy and show that in mixed spongy dystrophies the Leigh histology was associated with MA, but not the Canavan histology. Expand
Multifocal Subacute Necrotizing Encephalomyelopathy in Simmental Calves
TLDR
Occurrence of the syndrome within 1 breed over a wide geographic area suggests that hereditary factors contribute to development of MNE, and a similar defect in aerobic metabolism is hypothesized. Expand
Multifocal Polioencephalomyelomalacia in Simmental Calves with Elevated Tissue Aluminum and Decreased Tissue Copper and Manganese
TLDR
Focusing on Simmental calves reared in Oregon, USA, with morphologic lesions similar to those described in Simmental multifocal symmetrical encephalopathy, multifocal polioencephalomyelomalacia is described. Expand
Ultrastructural changes in isoniazid-induced brain oedema in the dog
TLDR
In the high-dose animals, focal areas of expanded extracellular space as well as evidence of damaged blood vessels, were seen in the cerebral cortex, and it could not be determined if these changes represented early lesions or resulted from perfusion artefact. Expand
Mitochondrial myopathies with necrotizing encephalopathy of the Leigh type.
TLDR
In two patients with mitochondrial encephalomyopathy (MEP) neuropathologically criteria of Leigh's syndrome could be demonstrated in the cerebral cortex, in case 2 also clinically. Expand
Caprine Encephalomyelomalacia
TLDR
Six cases of encephalomyelomalacia in dairy goats 3½ to four months of age are described and all goats were killed after six to ten days and had spinal cord and brain stem lesions—always more extensive and severe in the cord. Expand
An encephalomyelopathy in related Birman kittens.
The clinical and morphological features of an encephalomyelopathy in five related Birman kittens are described. The five kittens showed hind limb paresis and ataxia which progressed to hind limbExpand
Congenital tremor with spongy degeneration of the central nervous system in two puppies.
TLDR
Two crossbred puppies exhibited a generalized tremor that was accentuated by excitement or voluntary movement and Neurohistologic examination showed a bilaterally symmetric spongy condition, predominantly of the gray matter in the brain and spinal cord. Expand
...
1
2
3
4
...