Hereditary otovestibular dysfunction and Ménière's disease in a large Belgian family is caused by a missense mutation in the COCH gene.

@article{Verstreken2001HereditaryOD,
  title={Hereditary otovestibular dysfunction and M{\'e}ni{\`e}re's disease in a large Belgian family is caused by a missense mutation in the COCH gene.},
  author={Margriet Verstreken and Frank Declau and Floris L. Wuyts and Patrick D'haese and Guy Van Camp and Erik Frans{\'e}n and Luc van den Hauwe and Sonja Buyle and R M Erica Smets and Louw Feenstra and Anja Van der Stappen and Paul Van de Heyning},
  journal={Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology},
  year={2001},
  volume={22 6},
  pages={874-81}
}
OBJECTIVE To report the clinical, auditory, and vestibular characteristics of a nonsyndromic otovestibular dysfunction in a large Belgian family caused by a missense mutation of the DFNA9 gene: COCH. STUDY DESIGN Retrospective study of the clinical, audiologic, and vestibular data of 60 genetically affected cases. SETTING Tertiary referral center. PATIENTS All members of a Belgian kindred who carry the genetic (P51S) defect linked to the inherited hearing and vestibular impairment… CONTINUE READING