A deletion mutation in bovine SLC4A2 is associated with osteopetrosis in Red Angus cattle
A premature stillborn purebred Aberdeen-Angus calf with a short lower jaw and protruding tongue was the first of 23 such calves born in three herds during the i96o’s. Detailed pathologic examination revealed osteopetrosis, a disturbed relationship between bone formation and resorption (LEIPOLD et al., I97I ). A similar pathologic condition was described in 2 other herds of the same breed (T HOMPSON ,i966 ; LE Iror,n et al., i97 o). To be presented here is the evidence pertinent to the inheritance of bovine osteopetrosis.