Hereditary nonpolyposis colorectal cancer in 95 families: differences and similarities between mutation-positive and mutation-negative kindreds.

@article{Scott2001HereditaryNC,
  title={Hereditary nonpolyposis colorectal cancer in 95 families: differences and similarities between mutation-positive and mutation-negative kindreds.},
  author={Rodney J. Scott and Mike McPhillips and Cliff J. Meldrum and P E Fitzgerald and Kate Adams and Allan D. Spigelman and Desir{\'e}e du Sart and Kathy Tucker and Jeremy M. W. Kirk},
  journal={American journal of human genetics},
  year={2001},
  volume={68 1},
  pages={118-127}
}
Hereditary nonpolyposis colorectal cancer (HNPCC) describes the condition of a disparate group of families that have in common a predisposition to colorectal cancer in the absence of a premalignant phenotype. The genetic basis of this disease has been linked to mutations in genes associated with DNA mismatch repair. A large proportion of families harbor changes in one of two genes, hMSH2 and hMLH1. Approximately 35% of families in which the diagnosis is based on the Amsterdam criteria do not… CONTINUE READING

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