Hereditary motor neuropathies and motor neuron diseases: which is which.

  title={Hereditary motor neuropathies and motor neuron diseases: which is which.},
  author={Clemens Oliver Hanemann and Albert Christian Ludolph},
  journal={Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases},
  volume={3 4},
When Charcot first defined amyotrophic lateral sclerosis (ALS) he used the clinical and neuropathological pattern of vulnerability as a guideline. Similarly other motor neuron diseases such as the spinal muscular atrophies (SMA) and the motor neuropathies (MN) were grouped following clinical criteria. However, ever since the etiology of these diseases has started to be disclosed by genetics, we have learnt that the limits of the syndromes are not as well defined as our forefathers thought. A… CONTINUE READING


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