Hereditary lung cancer syndrome targets never smokers with germline EGFR gene T790M mutations.

@article{Gazdar2014HereditaryLC,
  title={Hereditary lung cancer syndrome targets never smokers with germline EGFR gene T790M mutations.},
  author={Adi F. Gazdar and Linda H Robinson and Dwight H. Oliver and Chao Xing and William D Travis and Junichi Soh and Shinichi Toyooka and Lori Meril Watumull and Yang Xie and Kemp H. Kernstine and Joan Hoff Schiller},
  journal={Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer},
  year={2014},
  volume={9 4},
  pages={456-63}
}
INTRODUCTION Hereditary lung cancer syndromes are rare, and T790M germline mutations of the epidermal growth factor receptor (EGFR) gene predispose to the development of lung cancer. The goal of this study was to determine the clinical features and smoking status of lung cancer cases and unaffected family members with this germline mutation and to estimate its incidence and penetrance. METHODS We studied a family with germline T790M mutations over five generations (14 individuals) and… CONTINUE READING
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