Hereditary leucodystrophy in the mouse: the new mutant twitcher.

@article{Duchen1980HereditaryLI,
  title={Hereditary leucodystrophy in the mouse: the new mutant twitcher.},
  author={L. W. Duchen and Eva M. Eicher and Jean M. Jacobs and Francesco Scaravilli and Fernanda Teixeira},
  journal={Brain : a journal of neurology},
  year={1980},
  volume={103 3},
  pages={
          695-710
        }
}
  • L. W. Duchen, Eva M. Eicher, +2 authors Fernanda Teixeira
  • Published in
    Brain : a journal of…
    1980
  • Biology, Medicine
  • A new inherited neurological disease in the mouse (the mutant twitcher) has been studied. Transmission is by an autosomal recessive gene (twi). Affected animals are apparently normal at birth but develop a generalized tremor at about 3 weeks of age followed by progressive weakness and wasting. The disease is fatal by 3 months. The principal pathological changes affect the myelin of both central and peripheral nervous systems. Degeneration of myelin sheaths and the presence of multinucleated… CONTINUE READING

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