Hereditary iron overload: update on pathophysiology, diagnosis, and treatment.

  title={Hereditary iron overload: update on pathophysiology, diagnosis, and treatment.},
  author={Massimo Franchini},
  journal={American journal of hematology},
  volume={81 3},
Hereditary hemochromatosis, a very common genetic defect in the Caucasian population, is characterized by progressive tissue iron overload which leads to irreversible organ damage if it is not treated timely. The elucidation of the molecular pathways of iron transport through cells and its control has led to the understanding of various genetic iron-loading conditions. Four types of inherited iron overload have been recognized: type 1, the most common form with an autosomal recessive… CONTINUE READING


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