Hereditary hemochromatosis.

  title={Hereditary hemochromatosis.},
  author={Brian K. Crownover and Carlton J. Covey},
  journal={American family physician},
  volume={87 3},
Hereditary hemochromatosis is an autosomal recessive disorder that disrupts the body's regulation of iron. It is the most common genetic disease in whites. Men have a 24-fold increased rate of iron-overload disease compared with women. Persons who are homozygous for the HFE gene mutation C282Y comprise 85 to 90 percent of phenotypically affected persons. End-organ damage or clinical manifestations of hereditary hemochromatosis occur in approximately 10 percent of persons homozygous for C282Y… CONTINUE READING
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