Hereditary hemochromatosis: awareness and genetic testing acceptability in Western Romania.


AIMS a public health strategy to promote early diagnosis of hemochromatosis gene (HFE)-related hemochromatosis (HFE-HH) largely depends on people's acceptance of available screening tests. The present study aimed at evaluating patient awareness of HFE-HH and their acceptance of DNA testing in western Romania. RESULTS a total of 221 participants were randomly recruited from the ambulatory unit of the Emergency County Hospital in Timisoara, Romania. They received brief information on HFE-HH and were assessed for the signs and symptoms of hemochromatosis. HFE genotyping was offered to all of them. Only two cases (0.9%) had previous knowledge of HFE-HH. Twenty-one cases (9.5%) underwent genetic testing. Characteristics associated with test acceptance were age <45 years, male gender, and educational attainment. Acceptance was associated with a desire to know if they had HFE-HH (85.7%). The most prevalent refusal reason was a desire for more information (41%). CONCLUSIONS larger educational programs are required to increase people's awareness about HFE-HH in western Romania. Nevertheless, within health care settings, the importance of disease detection and patient's educational background appear to be essential for achieving high rates of participation in the genetic test.

DOI: 10.1089/gtmb.2010.0109

Cite this paper

@article{Neghin2010HereditaryHA, title={Hereditary hemochromatosis: awareness and genetic testing acceptability in Western Romania.}, author={Adriana Maria Neghină and Andrei Anghel}, journal={Genetic testing and molecular biomarkers}, year={2010}, volume={14 6}, pages={847-50} }