Hereditary diabetes insipidus: an immunohistochemical study of the hypothalamus and pituitary gland

@article{Bergeron1991HereditaryDI,
  title={Hereditary diabetes insipidus: an immunohistochemical study of the hypothalamus and pituitary gland},
  author={Catherine Racicot Bergeron and Krisztina Kov{\'a}cs and Calvin Ezrin and Craig Mizzen},
  journal={Acta Neuropathologica},
  year={1991},
  volume={81},
  pages={345-348}
}
We report the histological findings in a case of hereditary diabetes insipidus (HDI) using vasopressin (VP) immunohistochemistry. The hypothalamus displayed a marked loss of magnocellular VP neurons, with preservation of the smaller cells. The neurohypophysis was severely atrophic with scanty immunoreactivity. Our results support the hypothesis that HDI results from a selective degeneration of VP neurons affecting chiefly the magnocellular elements projecting to the neurohypophysis. The sparing… CONTINUE READING
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