Hereditary deficiency of protein C or protein S confers increased risk of arterial thromboembolic events at a young age: results from a large family cohort study.

@article{Mahmoodi2008HereditaryDO,
  title={Hereditary deficiency of protein C or protein S confers increased risk of arterial thromboembolic events at a young age: results from a large family cohort study.},
  author={Bakhtawar Khan Mahmoodi and J. P. Brouwer and Nic J. G. M. Veeger and Jan B. van der Meer},
  journal={Circulation},
  year={2008},
  volume={118 16},
  pages={1659-67}
}
BACKGROUND Whether hereditary protein S, protein C, or antithrombin deficiency is associated with arterial thromboembolism (ATE) and whether history of venous thromboembolism in these subjects predisposes them to subsequent ATE have yet to be determined. METHODS AND RESULTS On the basis of pedigree analysis, we enrolled a total of 552 subjects (52% women; mean age, 46+/-17 years), belonging to 84 different kindreds, in this retrospective family cohort study. Detailed information on previous… CONTINUE READING

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