Hereditary colorectal cancer syndromes: molecular genetics, genetic counseling, diagnosis and management

@article{Lynch2007HereditaryCC,
  title={Hereditary colorectal cancer syndromes: molecular genetics, genetic counseling, diagnosis and management},
  author={Henry T. Lynch and Jane F. Lynch and Patrick M Lynch and Thomas Attard},
  journal={Familial Cancer},
  year={2007},
  volume={7},
  pages={27-39}
}
Hereditary forms of colorectal cancer, as is the case with virtually all forms of hereditary cancer, show extensive phenotypic and genotypic heterogeneity, a phenomenon discussed throughout this special issue of Familial Cancer. Clearly, the family physician, oncology specialist, genetic counselor, and cancer geneticist must know fully the complexity of hereditary cancer syndromes, their differential diagnosis, in order to establish a diagnosis, direct highly-targeted surveillance and… 
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How medical geneticists are beginning to incorporate cancer genome data into clinical practice is described, which will need to consider both the constitutional and cancer genome when making clinical decisions.
Molecular diagnosis of hereditary nonpolyposis colorectal cancer (Lynch syndrome)
TLDR
Different approaches proposed by several researchers on molecular algorithms to improve the efficiency of Lynch syndrome diagnosis are presented.
Psychological Impact of Genetic Counseling and Testing for Hereditary Colorectal Cancers
TLDR
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TLDR
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Novel genetic mutations detected by multigene panel are associated with hereditary colorectal cancer predisposition
TLDR
Multigene panel testing is a more effective method to identify germline variants in cancer patients compared to single-gene approaches and should be therefore included in clinical laboratories.
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