Hereditary colorectal cancer in the general population: from cancer registration to molecular diagnosis.

@article{Leon1999HereditaryCC,
  title={Hereditary colorectal cancer in the general population: from cancer registration to molecular diagnosis.},
  author={Maurizio Ponz de Leon and Monica Pedroni and Piero Benatti and Antonio Percesepe and Carmela Di Gregorio and Moira Foroni and Giuseppina Rossi and Maurizio Genuardi and Giovanni Neri and Francesca Leonardi and Alessandra Viel and Eugenia Capozzi and Mauro Boiocchi and Luca Roncucci},
  journal={Gut},
  year={1999},
  volume={45 1},
  pages={
          32-8
        }
}
BACKGROUND Hereditary non-polyposis colorectal cancer (HNPCC) is one of the most common inherited disorders predisposing to cancer. The genes responsible for the disease have recently been cloned and characterised; their mutations induce a generalised genomic instability which is particularly evident at microsatellite loci (replication error (RER)+ phenotype). AIMS To investigate how to select individuals and families in the general population who should be screened for constitutional… CONTINUE READING
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