Hereditary chronic conjugated hyperbilirubinemia in mutant rats caused by defective hepatic anion transport.

@article{Jansen1985HereditaryCC,
  title={Hereditary chronic conjugated hyperbilirubinemia in mutant rats caused by defective hepatic anion transport.},
  author={Petra Lynen Jansen and Wilbert H. M. Peters and Wouter H. Lamers},
  journal={Hepatology},
  year={1985},
  volume={5 4},
  pages={
          573-9
        }
}
A mutant rat strain is described with autosomal recessive conjugated hyperbilirubinemia. Transport of conjugated bilirubin and tetrabromosulfophthalein from liver to bile is severely impaired whereas uptake of organic anions from plasma to liver is normal. During the first 10 days of life, serum bilirubin levels are 147 +/- 11 mumoles per liter with 68.7% diconjugates and 27.9% monoconjugates. In adult rats, serum bilirubin is 33 +/- 8 mumoles per liter with 81.8% diconjugates and 12.1… CONTINUE READING
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