Hereditary cardiomyopathy in W/SSM rats: Biochemical mechanisms of development


One mechanism shown to be responsible for the occurrence of hypertrophic cardiomyopathy in rats of the W/SSM strain, in which this disease is genetically determined, is impairment of cellular membrane integrity resulting from increased hexose transport to cells, generation of hydroxyl radicals, and intensified lipid peroxidation. 
DOI: 10.1007/BF02445956

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