Hereditary breast cancer in Jews

@article{Rubinstein2004HereditaryBC,
  title={Hereditary breast cancer in Jews},
  author={Wendy S. Rubinstein},
  journal={Familial Cancer},
  year={2004},
  volume={3},
  pages={249-257}
}
A family history of breast cancer poses higher risks for Jewish versus non-Jewish women, particularly for early-onset breast cancer. This appears to be due in large part to the high prevalence (2.5%) of three BRCA1 and BRCA2 founder mutations in Ashkenazi Jews. About 4 to 8% of non-Jewish male breast cancer cases versus 19% of Jewish male breast cancer cases carry germline BRCA mutations. Jewish women are disproportionately impacted by BRCA mutations throughout life, with a 10% carrier rate for… CONTINUE READING
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