Hereditary breast cancer: ever more pieces to the polygenic puzzle

@inproceedings{Bogdanova2013HereditaryBC,
  title={Hereditary breast cancer: ever more pieces to the polygenic puzzle},
  author={Natalia Valerijevna Bogdanova and Sonja Helbig and Thilo D{\"o}rk},
  booktitle={Hereditary cancer in clinical practice},
  year={2013}
}
Several susceptibility genes differentially impact on the lifetime risk for breast cancer. Technological advances over the past years have enabled the detection of genetic risk factors through high-throughput screening of large breast cancer case-control series. High- to intermediate penetrance alleles have now been identified in more than 20 genes involved in DNA damage signalling and repair, and more than 70 low-penetrance loci have been discovered through recent genome-wide association… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 4 times over the past 90 days. VIEW TWEETS
17 Citations
156 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 156 references

Collaborative Group on Hereditary Breast and Ovarian Cancer

  • M Ghoussaini, O Fletcher, +20 authors Netherlands
  • Nat Genet
  • 2012
Highly Influential
5 Excerpts

Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk

  • N Orr, A Lemnrau, +28 authors M Krajc
  • Nat Genet
  • 2012
Highly Influential
5 Excerpts

Similar Papers

Loading similar papers…