Hereditary adult-onset leukodystrophy simulating chronic progressive multiple sclerosis.

  title={Hereditary adult-onset leukodystrophy simulating chronic progressive multiple sclerosis.},
  author={Roswell Eldridge and C P Anayiotos and Sorina E Schlesinger and D Patrick Cowen and Christopher T. Bever and Nicholas Patronas and H. McFarland},
  journal={The New England journal of medicine},
  volume={311 15},
We studied a large kindred with a chronic progressive neurologic disorder affecting at least 10 men and 11 women in four generations in a pattern compatible with autosomal dominant inheritance. In 20 of the affected subjects, evaluated before the availability of computerized tomography and without regard to family history, the diagnosis was multiple sclerosis. Symptoms of the neurologic disorder begin in the fourth and fifth decades and include cerebellar, pyramidal, and autonomic abnormalities… CONTINUE READING
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