Herding Hippos: regulating growth in flies and man.

@article{Badouel2009HerdingHR,
  title={Herding Hippos: regulating growth in flies and man.},
  author={Caroline Badouel and Ankush Garg and Helen McNeill},
  journal={Current opinion in cell biology},
  year={2009},
  volume={21 6},
  pages={837-43}
}
Control of cell number requires the coordinate regulation of cell proliferation and cell death. Studies in both the fly and mouse have identified the Hippo kinase pathway as a key signaling pathway that controls cell proliferation and apoptosis. Several studies have implicated the Hippo pathway in a variety of cancers. Recent studies have also revealed a role for the Hippo pathway in the control of cell fate decisions during development. In this review, we will cover the current model of Hippo… CONTINUE READING

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