Herd immunity by infection is not an option

  title={Herd immunity by infection is not an option},
  author={Devi Sridhar and Deepti Gurdasani},
  pages={230 - 231}
Difficult lessons are learned from a largely uncontrolled COVID-19 epidemic in Manaus, Brazil Herd immunity is expected to arise when a virus cannot spread readily, because it encounters a population that has a level of immunity that reduces the number of individuals susceptible to infection. On page 288 of this issue, Buss et al. (1) describe the extent of the largely uncontrolled severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic in Manaus, the capital of Amazonas state in… Expand
Beyond the new normal: assessing the feasibility of vaccine-based elimination of SARS-CoV-2
It is suggested that vaccines that do not prevent infection will allow extensive endemic SARS-CoV-2 spread upon a return to pre-pandemic social and economic conditions and vaccines that only reduce symptomatic CO VID-19 or mortality will fail to mitigate serious COVID-19 mortality risks. Expand
A framework for monitoring population immunity to SARS-CoV-2
To guide vaccine roll-out and other aspects of control over the coming months, analytics that combine vaccine coverage with local (e.g. county-level) history of case reports and adjustment for waning antibodies to establish local estimates of population immunity are recommended. Expand
Prospects for durable immune control of SARS-CoV-2 and prevention of reinfection
The dynamics of memory responses to SARS-CoV-2 and the mechanisms of immune control are crucial for the rational design and deployment of vaccines and for understanding the possible future trajectories of the pandemic. Expand
Beyond the new normal: Assessing the feasibility of vaccine-based suppression of SARS-CoV-2
It is suggested that a return to pre-pandemic social and economic conditions without fully suppressing SARS-CoV-2 will lead to extensive viral spread, resulting in a high disease burden even in the presence of vaccines that reduce risk of infection and mortality. Expand
A control framework to optimize public health policies in the course of the COVID-19 pandemic
It is shown the importance of finely tuning the levels of enforced measures to achieve SARS-CoV-2 containment, with periodic interventions emerging as an optimal control strategy in the long-term. Expand
What the COVID-19 pandemic reveals about science, policy and society
The global COVID-19 pandemic of 2020–2021 required politicians to work alongside and depend on scientists more closely than any other event in recent times. It also saw science unfold in real timeExpand
Interpreting airborne pandemics spreading using fractal kinetics’ principles
Introduction  The reaction between susceptible and infected subjects has been studied under the well-mixed hypothesis for almost a century. Here, we present a consistent analysis for a not well-mixedExpand
A forensic analysis of SARS-CoV-2 cases and COVID-19 mortality misreporting in the Brazilian population
A significant rejection of SARS-CoV-2 notification cases at the city and the number of deaths by COVID-19 in all regional levels according to the hypothesis of conformity to Benford’s law (BL) is demonstrated. Expand
The mathematics of multiple lockdowns
It is shown that repeated lockdowns have a beneficial effect, reducing the final size of the infection, and that they represent a possible support strategy to vaccination policies. Expand
Primary Care Interventions to Address COVID-19 Vaccine Hesitancy Among Israel Defense Forces Soldiers
On-site COVID-19 vaccine rollout joined with primary care communication interventions may maximize vaccine uptake within a young-adult community and should evaluate the effectiveness of these efforts across different populations in a controlled and comparative manner. Expand


Lessons learnt from easing COVID-19 restrictions: an analysis of countries and regions in Asia Pacific and Europe
This Health Policy paper uses an adapted framework to examine the approaches taken by nine high-income countries and regions that have started to ease COVID-19 restrictions: five in the Asia Pacific region (ie, Hong Kong [Special Administrative Region], Japan, New Zealand, Singapore, and South Korea) and four in Europe (IE, Germany, Norway, Spain, and the UK). Expand
Seasonal coronavirus protective immunity is short-lasting.
It is determined that reinfection with the same seasonal coronavirus occurred frequently at 12 months after infection, and insights from infections with the four seasonal human coronaviruses might reveal common characteristics applicable to all humans. Expand
Evidence of thrombotic microangiopathy in children with SARS-CoV-2 across the spectrum of clinical presentations
A high proportion of tested children with SARS-CoV-2 infection had evidence of complement activation and met clinical and diagnostic criteria for TMA, and if there are any short- or long-term clinical consequences of complementactivation and endothelial damage in children with COVID-19 or MIS-C is needed. Expand