Herbimycin A in the treatment of experimental proliferative vitreoretinopathy: toxicity and efficacy study

@article{Imai2000HerbimycinAI,
  title={Herbimycin A in the treatment of experimental proliferative vitreoretinopathy: toxicity and efficacy study},
  author={Kazuyuki Imai and Anat Loewenstein and Barba Koroma and Rhonda R Grebe and E. De Juan},
  journal={Graefe's Archive for Clinical and Experimental Ophthalmology},
  year={2000},
  volume={238},
  pages={440-447}
}
Background: Proliferative vitreoretinopathy (PVR) is partially caused by peptide growth factors, stimulating the cell by binding to a transmembrane tyrosine kinase receptor. We studied the effects of herbimycin A (HA), a tyrosine kinase inhibitor, in PVR.  Methods: Toxicity studies: Electroretinography and histological studies were performed after intravitreal injection of HA. Efficacy studies: Homologous rabbit dermal fibroblasts were injected intravitreally, followed by injection of HA. The… CONTINUE READING

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