Herbicide-binding sites revealed in the structure of plant acetohydroxyacid synthase.

  title={Herbicide-binding sites revealed in the structure of plant acetohydroxyacid synthase.},
  author={Jennifer A McCourt and Siew Siew Pang and Jack King-Scott and Luke W. Guddat and R. G. Duggleby},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={103 3},
The sulfonylureas and imidazolinones are potent commercial herbicide families. They are among the most popular choices for farmers worldwide, because they are nontoxic to animals and highly selective. These herbicides inhibit branched-chain amino acid biosynthesis in plants by targeting acetohydroxyacid synthase (AHAS, EC This report describes the 3D structure of Arabidopsis thaliana AHAS in complex with five sulfonylureas (to 2.5 A resolution) and with the imidazolinone, imazaquin… CONTINUE READING


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Pesticide Synthesis Through Rational Approaches

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