Herbal melanin activates TLR4/NF-kappaB signaling pathway.

@article{Oberg2009HerbalMA,
  title={Herbal melanin activates TLR4/NF-kappaB signaling pathway.},
  author={Fredrik Oberg and Adil M Haseeb and Matilda Ahnfelt and Fredrik Pont{\'e}n and Bengt Westermark and Adila El-Obeid},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year={2009},
  volume={16 5},
  pages={477-84}
}
Expression of many pro-inflammatory cytokines is controlled by the NF-kappaB signaling pathway. NF-kappaB is induced by LPS through activation of TLR4. Melanins extracted from fungal, plant and human sources modulate cytokine production and activate NF-kappaB pathway. We showed that a herbal melanin (HM) from Nigella sativa L. modulates cytokine production and suggested it as a ligand for TLR4. In this study we investigated the possibility that the HM-induced cytokine production is via an NF… CONTINUE READING

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