Herbal Insomnia Medications that Target GABAergic Systems: A Review of the Psychopharmacological Evidence

  title={Herbal Insomnia Medications that Target GABAergic Systems: A Review of the Psychopharmacological Evidence},
  author={Yuan Shi and Jing-wen Dong and Jiang-He Zhao and Lina Tang and Jian-jun Zhang},
  journal={Current Neuropharmacology},
  pages={289 - 302}
Insomnia is a common sleep disorder which is prevalent in women and the elderly. Current insomnia drugs mainly target the γ-aminobutyric acid (GABA) receptor, melatonin receptor, histamine receptor, orexin, and serotonin receptor. GABAA receptor modulators are ordinarily used to manage insomnia, but they are known to affect sleep maintenance, including residual effects, tolerance, and dependence. In an effort to discover new drugs that relieve insomnia symptoms while avoiding side effects… 

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