Herbal Dietary Supplements for Erectile Dysfunction: A Systematic Review and Meta-Analysis

  title={Herbal Dietary Supplements for Erectile Dysfunction: A Systematic Review and Meta-Analysis},
  author={Francesca Borrelli and Cristiano Colalto and Domenico Vittorio Delfino and Marcello Iriti and Angelo A. Izzo},
PurposeErectile dysfunction (ED) is a common condition that significantly affects quality of life and interpersonal relationships.ObjectiveOur objective was to perform a systematic review and meta-analysis to evaluate the efficacy of herbal dietary supplements in the treatment of ED.Materials and MethodsWe searched five databases to identify randomized controlled trials (RCTs) that evaluated the clinical efficacy of herbal medicines in ED. Quality was assessed and risk of bias was estimated… 
Alternative medicine and herbal remedies in the treatment of erectile dysfunction: A systematic review
ABSTRACT Objectives: To systematically review and discuss the current evidence from placebo-controlled clinical trials that investigated the use of alternative medicines and herbal remedies in the
Effectiveness of Ginseng in Treating Erectile Dysfunction: A Review Paper
It was concluded that ginseng is a feasible alternative to currently available practices in treating ED due to a significant improvement in International Index of Erectile Function (IIEF)-5 scores and its safety profile.
A review on the role of oral ginseng on erection dysfunction and fatigue in prostate cancer patients
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Toward a Scientific Nutritional Supplement Combination for Prostatism and Erectile Dysfunction I: From Known Pharmacology to Clinical Testing.
  • R. Pyke
  • Medicine
    Journal of medicinal food
  • 2019
The goal is to develop an effective NS for prostatism and ED using the MoA of prescription treatments using the most promising NS employing these MoA, and pilot testing of a combination NS with the best-supported MoA supported further development.
Considerations for prescribing pharmacotherapy for the treatment of erectile dysfunction
A thorough investigation of considerations for prescribing ED pharmacotherapy is still lacking in the literature, and several issues should be considered in the planning of ED management such as the patient's and partner’s expectations, etiologic considerations, performance status, safety, adverse effects, ease of administration, compliance, and finally, regimen considerations.
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Alternative treatments, like l -arginine, have a growing body of evidence for efficacy in combination with PDE5i, and low-intensity shock wave therapy and stem cell therapy continue to demonstrate encouraging outcomes in ED trials.
Plant-Derived Supplements for Sexual Health and Problems, Part 2: Further Evidence for Specific Herbal Effects
Burgeoning interest in phytochemical research over the past decade has helped to elucidate potential mechanisms of action through which plant-derived supplements may exert pro-sexual benefits, but more methodologically rigorous, large-scale clinical trials are still needed to determine the extent to which encouraging findings in rodent, cell culture, and ex vivo models are generalizable to human populations.
Pharmacotherapy for Erectile Dysfunction in 2021 and Beyond.


Red ginseng for treating erectile dysfunction: a systematic review.
Collectively these RCTs provide suggestive evidence for the effectiveness of red ginseng in the treatment of erectile dysfunction, but the total number of R CTs included in the analysis, the total sample size and the methodological quality of the primary studies were too low to draw definitive conclusions.
Chinese herb formulae for treatment of erectile dysfunction: a systematic review of randomised controlled clinical trials
It was concluded that some therapies of CHF may be more effective than the controls for treatment of ED, however, because of the generally not low risks of bias, CHF are not recommended for ED.
Evaluation of a multi-herb supplement for erectile dysfunction: a randomized double-blind, placebo-controlled study
VigRX Plus was well tolerated and more effective than placebo in improving sexual function in men, in a double blind, randomized placebo-controlled, parallel groups, multi-centre study.
Panax ginseng in Randomised Controlled Trials: A Systematic Review
P. ginseng shows promising results for improving glucose metabolism and moderating the immune response, which may have implications for several diseases including type 2 diabetes and chronic respiratory conditions.
Ginseng for Health Care: A Systematic Review of Randomized Controlled Trials in Korean Literature
Although the quality of RCTs published in the Korean literature was generally poor, this review is useful for researchers to access studies that were originally published in languages that they would otherwise be unable to read and due to the paucity of evidence on this subject.
Clinical efficacy of Korean red ginseng for erectile dysfunction.
Possible breakthrough in treatment of erectile dysfunction could be arisen from active saponin extracted from red ginseng, bringing hopes to many sufferers of erectiles dysfunction.
Study of the efficacy of Korean Red Ginseng in the treatment of erectile dysfunction.
The data show that KRG can be an effective alternative to the invasive approaches for treating male ED.
Effects of a Topical Saffron (Crocus sativus L) Gel on Erectile Dysfunction in Diabetics
Compared to placebo, the prepared saffron gel could significantly improve erectile dysfunction in diabetic patients (P < .001).