Herb-drug interaction of 50 Chinese herbal medicines on CYP3A4 activity in vitro and in vivo.

@article{Pao2012HerbdrugIO,
  title={Herb-drug interaction of 50 Chinese herbal medicines on CYP3A4 activity in vitro and in vivo.},
  author={L H Pao and Oliver Yoa-Pu Hu and Hsien-Yuan Fan and Chun-Cheng Lin and Liang-Chun Liu and Pei-Wei Huang},
  journal={The American journal of Chinese medicine},
  year={2012},
  volume={40 1},
  pages={57-73}
}
The purpose of this study is to evaluate the effects of Chinese herbal medicines on the enzymatic activity of CYP3A4 and the possible metabolism-based herb-drug interactions in human liver microsomes and in rats. Fifty single-herbal preparations were screened for the activity of CYP3A4 using human liver microsomes for an in vitro probe reaction study. The enzymatic activity of CYP3A4 was estimated by determing the 6β-hydroxytestosterone metabolized from testosterone performed on a liquid… CONTINUE READING

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