Herb-Drug Interactions

@article{Hu2012HerbDrugI,
  title={Herb-Drug Interactions},
  author={Zeping Hu and Xiaoxia Yang and Paul Chi-lui Ho and Sui Yung Chan and Paul Wan Sia Heng and Eli Chan and Wei Duan and Hwee-Ling Koh and Shufeng Zhou},
  journal={Drugs},
  year={2012},
  volume={65},
  pages={1239-1282}
}
AbstractHerbs are often administered in combination with therapeutic drugs, raising the potential of herb-drug interactions. An extensive review of the literature identified reported herb-drug interactions with clinical significance, many of which are from case reports and limited clinical observations.Cases have been published reporting enhanced anticoagulation and bleeding when patients on long-term warfarin therapy also took Salvia miltiorrhiza (danshen). Allium sativum (garlic) decreased… 
Herb–Drug and Food–Drug Interactions
TLDR
Much of the published evidence on herb–drug and food–drug interactions is based on case reports or on pharmacokinetic data alone, and these require substantiation by studies measuring the clinical effects of drugs.
Inhibition of CYP2C9 by natural products: insight into the potential risk of herb-drug interactions
TLDR
For the purpose of better understanding the interactions of natural products with CYP2C9, a comprehensively reviewed the characteristics of CYP1C8, the natural ingredients that inhibit CYP9, the related research approaches and strategies, the types of inhibition and the underlying mechanisms.
Toxicology, Safety and Herb–drug Interactions in Cancer Therapy
TLDR
Timely identification of the herbal medicines involved and victim anticancer drugs is important to remind both oncologists and cancer patients of the possible safety concerns arising from combined use of herbs with any antic cancer drugs.
Herb-drug interactions involving drug metabolizing enzymes and transporters.
TLDR
This review highlights recent knowledge to discuss herb-drug interactions involving metabolizing enzymes and transporters in drug- drug interactions.
Combination therapy of Western drugs and herbal medicines: recent advances in understanding interactions involving metabolism and efflux
TLDR
This work discusses pharmacokinetic interactions between different therapeutic classes of Western drugs and herbal medicines, and discusses herb–drug interactions from both in vitro and in vivo studies with specific focus on recent findings.
Pharmacokinetics of Anticancer Materia Medica in Humans
TLDR
A safe and optimal use of anticancer herbal medicines requires a full understanding of their pharmacokinetic profiles, and further studies to explore their Pharmacokinetic properties in humans are certainly warranted.
Interaction Between Traditional Chinese Medicine and Anticoagulant/antiplatelet Drugs.
TLDR
The herb-drug interactions between TCM and anticoagulant/antiplatelet drugs should be further explored and defined to provide guidance on concomitant ingestion with antICOagulants and antiplatelets with adverse reactions.
...
...

References

SHOWING 1-10 OF 642 REFERENCES
Herb-drug interactions
Herb–drug interactions: an overview of the clinical evidence
  • A. Izzo
  • Biology, Medicine
    Fundamental & clinical pharmacology
  • 2005
TLDR
For many of the interactions discussed here, the understanding of the mechanisms involved is incomplete, and taking herbal agents may represent a potential risk to patients under conventional pharmacotherapy.
Herbal medication: potential for adverse interactions with analgesic drugs
  • W. Abebe
  • Medicine, Biology
    Journal of clinical pharmacy and therapeutics
  • 2002
TLDR
Health‐care professionals should be more aware of the potential adverse interactions between herbal supplements and analgesic drugs, and take appropriate precautionary measures to avoid their possible occurrences.
Pharmacokinetic Interactions of Drugs with St John’s Wort
TLDR
The available data indicate that St John’s wort is a potent inducer of CYP 3A4 and P-glycoprotein (PgP), although it may inhibit or induce other CYPs, depending on the dose, route and duration of administration.
Pharmacokinetic interactions between herbal remedies and medicinal drugs
  • C. Ioannides
  • Biology, Medicine
    Xenobiotica; the fate of foreign compounds in biological systems
  • 2002
TLDR
In transplant patients, self-medication with St John's wort has led to a drop in plasma levels of the immunosuppressant drug cyclosporine, causing tissue rejection, and it is essential that the ability of herbal products to interfere with drug-metabolizing enzyme systems is fully established.
Pharmacogenetics and herb-drug interactions: experience with Ginkgo biloba and omeprazole.
TLDR
The results show that G biloba can induce omeprazole hydroxylation in a CYP2C19 genotype-dependent manner and concurrently reduce the renal clearance of 5-hydroxyomeprazole.
Interactions Between Herbal Medicines and Prescribed Drugs
TLDR
Interactions between herbal medicines and synthetic drugs exist and can have serious clinical consequences, and healthcare professionals should ask their patients about the use of herbal products and consider the possibility of herb-drug interactions.
Pharmacokinetic-Pharmacodynamic Consequences and Clinical Relevance of Cytochrome P450 3A4 Inhibition
TLDR
The clinical importance of any drug interaction depends on factors that are drug-, patient- and administration-related and is likely to be dependent on interindividual differences in CYP3A4 tissue content, pre-existing medical conditions and, possibly, age.
Drug–herb interactions: unexpected suppression of free Danshen concentrations by salicylate
TLDR
It is concluded that salicylate in therapeutic concentration can significantly decrease free Danshen concentrations, andDanshen can displace salicyllate from protein binding, thereby increasing the free salicYLate concentration.
...
...