Herb–Drug Interactions with St John’s Wort (Hypericum perforatum): an Update on Clinical Observations

@article{Borrelli2009HerbDrugIW,
  title={Herb–Drug Interactions with St John’s Wort (Hypericum perforatum): an Update on Clinical Observations},
  author={Francesca Borrelli and Angelo A Izzo},
  journal={The AAPS Journal},
  year={2009},
  volume={11},
  pages={710-727}
}
St John’s wort (SJW) extracts, prepared from the aerial parts of Hypericum perforatum, contain numerous pharmacologically active ingredients, including naphthodianthrones (e.g., hypericin and its derivatives), phloroglucinols derivatives (e.g., hyperforin, which inhibits the reuptake of a number of neurotransmitters, including serotonin), and flavonoids. Such extracts are widely used for the treatment of mild-to-moderate depression. As a monotherapy, SJW has an encouraging safety profile… CONTINUE READING
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