Her4 mediates ligand-dependent antiproliferative and differentiation responses in human breast cancer cells.

@article{Sartor2001Her4ML,
  title={Her4 mediates ligand-dependent antiproliferative and differentiation responses in human breast cancer cells.},
  author={Carolyn I. Sartor and Haiying Zhou and Ewa Kozlowska and Katherine L Guttridge and E Kawata and Laura S. Caskey and J C Harrelson and Nancy E. Hynes and Stephen P Ethier and Benjamin Calvo and H. Shelton Earp},
  journal={Molecular and cellular biology},
  year={2001},
  volume={21 13},
  pages={4265-75}
}
The function of the epidermal growth factor receptor (EGFR) family member HER4 remains unclear because its activating ligand, heregulin, results in either proliferation or differentiation. This variable response may stem from the range of signals generated by HER4 homodimers versus heterodimeric complexes with other EGFR family members. The ratio of homo- and heterodimeric complexes may be influenced both by a cell's EGFR family member expression profile and by the ligand or even ligand isoform… CONTINUE READING