Her4 and Her2/neu tyrosine kinase domains dimerize and activate in a reconstituted in vitro system.

Abstract

Her4 (ErbB-4) and Her2/neu (ErbB-2) are receptor-tyrosine kinases belonging to the epidermal growth factor receptor (EGFR) family. Crystal structures of EGFR and Her4 kinase domains demonstrate kinase dimerization and activation through an allosteric mechanism. The kinase domains form an asymmetric dimer, where the C-lobe surface of one monomer contacts the… (More)
DOI: 10.1074/jbc.M109.096032

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Cite this paper

@article{Monsey2010Her4AH, title={Her4 and Her2/neu tyrosine kinase domains dimerize and activate in a reconstituted in vitro system.}, author={John D Monsey and Wei Shen and Paul K. Schlesinger and Ron Bose}, journal={The Journal of biological chemistry}, year={2010}, volume={285 10}, pages={7035-44} }