Her-2/neu expression in prostate cancer: high level of expression associated with exposure to hormone therapy and androgen independent disease.


PURPOSE HER-2/neu is a proto-oncogene that encodes a transmembrane receptor belonging to the family of epidermal growth factor receptors. Increasing evidences indicates that HER-2/neu may contribute to hormone resistance in prostate cancer. We investigated HER-2/neu expression in primary, androgen dependent and advanced androgen independent prostate cancer… (More)


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