Heptapeptide semax attenuates the effects of chronic unpredictable stress in rats

  title={Heptapeptide semax attenuates the effects of chronic unpredictable stress in rats},
  author={K. A. Yatsenko and N. Yu. Glazova and Lyudmila S. Inozemtseva and Lyudmila A. Andreeva and A. A. Kamensky and Igor A. Grivennikov and Natalia G Levitskaya and Oleg V. Dolotov and Nikolay F. Myasoedov},
  journal={Doklady Biological Sciences},
353 Chronic stress is a risk factor of a number of pathol ogies, including depressive disorders [1], with a high degree of comorbidity of depression and anxiety disor ders [2]. In addition, in many patients with these pathologies, disturbance of cognitive functions has been observed [3]. In experiments on animals, it has been demonstrated that, in rats, chronic stress also causes cognitive disturbances and behavioral disor ders, including an elevated level of anxiety and depres sive like… 
The Protective Effect of Semax in a Model of Stress-Induced Impairment of Memory and Behavior in White Rats
Preliminary intraperitonial administration of Semax (0.1 mg/kg) attenuates cognitive impairment caused by acute restrained stress, but it does not affect stress-induced changes in anxiety.
Antistress Action of Melanocortin Derivatives Associated with Correction of Gene Expression Patterns in the Hippocampus of Male Rats Following Acute Stress
The antistress action of MC peptides may be associated with a correction of gene expression patterns that are disrupted during ARS, and both peptides upregulated the expression levels of many genes that displayed decreased expression after ARS and vice versa.
Influence of ACTG4-7-PGP (Semax) on Morphofunctional State of Hepatocytes in Chronic Emotional and Painful Stress
The decrease of hepatocyte cytolysis against the background of more intense morphological signs of protein synthesis processes attests to activation of reparative processes in the liver parenchyma via enhanced constitutional synthesis of protein.
Neuroprotective Effect of EDR Peptide in Mouse Model of Huntington's Disease
The data obtained prompt EDR peptide capability to restore the morphology of spines in striatum neurons in Huntington’s disease (HD) mouse model and the proposed model suggests that E DR peptide binds specific binding site oligo (dCG) along the DNA minor groove.
An integrated approach to study the molecular aspects of regulatory peptides biological mechanism.
The ability of heptapeptide Semax to modulate in dose-dependent manner [3 H]Ach and [ 3 H]GABA specific binding to some of its corresponding receptors as well as to affect the number of rat neurons plasmatic membranes after complex stress exposure is shown.
Investigation of the effect of a modified fragment of neuropeptide Y on memory phases and extrapolation escape of animals.
Peptide NP9 demonstrated the ability to improve memorization due to its effect on I phase of memory and facilitated extinction of negative experiences when administered after a stress stimulus and increased the cognitive ability of animals in the conditions an aversive environment in the extrapolation escape test.


Chronic Unpredictable Stress Induces a Cognitive Deficit and Anxiety-Like Behavior in Rats that is Prevented by Chronic Antidepressant Drug Treatment
In the present study, a rat model of chronic unpredictable stress (CUS) consistently induced a cognitive impairment in extradimensional set shifting capability in an attentional set shifting test, suggesting an alteration in function of the medial prefrontal cortex.
Glucocorticoids, depression, and mood disorders: structural remodeling in the brain.
  • B. McEwen
  • Psychology, Biology
    Metabolism: clinical and experimental
  • 2005
Chronic Mild Stress (CMS) Revisited: Consistency and Behavioural-Neurobiological Concordance in the Effects of CMS
  • P. Willner
  • Psychology, Biology
  • 2005
There is overwhelming evidence that under appropriate experimental conditions, CMS can cause antidepressant-reversible depressive-like effects in rodents; however, the ‘anomalous’ profile that is occasionally reported appears to be a genuine phenomenon, and these two sets of behavioural effects appear to be associated with opposite patterns of neurobiological changes.
Brain-Derived Neurotrophic Factor Produces Antidepressant Effects in Behavioral Models of Depression
The hypothesis that BDNF in the hippocampus produces an antidepressant effect in behavioral models of depression, the learned helplessness (LH) and forced swim test (FST) paradigms is tested and provides further support for the hypothesis thatBDNF contributes to the therapeutic action of antidepressant treatment.
Chronic stress elicits prolonged activation of α‐MSH secretion and subsequent degeneration of melanotroph
The findings suggest that prolonged stress suppressed hypothalamus‐derived dopamine release in IL, which elicited over‐secretion of α‐MSH from the melanotrophs, which suggests that prolonged hyperactivation of endocrine cells could lead to disorder of secretion mechanisms and eventual degeneration.
Early deprivation leads to altered behavioural, autonomic and endocrine responses to environmental challenge in adult Fischer rats
High sensitivity to an aversive early environment in male Fischer rats therefore constitutes an important model for the study of affective development and its neurobiology.
Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant
Rats exposed chronically to a variety of mild unpredictable stressors showed a reduced consumption of and preference for saccharin or sucrose solutions and DMI reduced blood corticosterone and glucose levels, but stress did not significantly alter either measure.
Comorbidity of anxiety and unipolar mood disorders.
Research on relationships between anxiety and depression has proceeded at a rapid pace since the 1980s, with data converging on an integrative hierarchical model of mood and anxiety disorders in which each individual syndrome contains both a common and a unique component.