Heptapeptide ligands against receptor-binding sites of influenza hemagglutinin toward anti-influenza therapy.

Abstract

The initial attachment of influenza virus to cells is the binding of hemagglutinin (HA) to the sialyloligosaccharide receptor; therefore, the small molecules that inhibit the sugar-protein interaction are promising as HA inhibitors to prevent the infection. We herein demonstrate that sialic acid-mimic heptapeptides are identified through a selection from a… (More)
DOI: 10.1016/j.bmc.2016.01.039

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