Heptaoxygenated xanthones as anti-austerity agents from Securidaca longepedunculata.

  title={Heptaoxygenated xanthones as anti-austerity agents from Securidaca longepedunculata.},
  author={Dya Fita Dibwe and Suresh Awale and Shigetoshi Kadota and Hiroyuki Morita and Yasuhiro Tezuka},
  journal={Bioorganic & medicinal chemistry},
  volume={21 24},
In a course of our search for anticancer agent based on a novel anti-austerity strategy, we found that the CHCl3 extract of the roots of Securidaca longepedunculata (Polygalaceae), collected at Democratic Republic of Congo, killed PANC-1 human pancreatic cancer cells preferentially in nutrient-deprived medium (NDM). Phytochemical investigation on the CHCl3 extract led to the isolation of 28 compounds including five new polymethoxylated xanthones [1,6,8-trihydroxy-2,3,4,5-tetramethoxyxanthone (1… CONTINUE READING
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