Heptahelical Receptor Signaling: Beyond the G Protein Paradigm

@article{Hall1999HeptahelicalRS,
  title={Heptahelical Receptor Signaling: Beyond the G Protein Paradigm },
  author={Randy A. Hall and Richard T Premont and Robert J Lefkowitz},
  journal={The Journal of Cell Biology},
  year={1999},
  volume={145},
  pages={927 - 932}
}
H EPTAHELICAL receptors, so called because of their conserved structure featuring seven a -helical transmembrane spans, mediate physiological responses to a remarkably diverse array of stimuli. These include hormones, neurotransmitters, small peptides, proteins, lipids and ions, as well as sensory stimuli such as odorants, pheromones, bitter and sweet tastants, and photons. This superfamily of receptors contains . 1,000 members, making it the largest class of cell surface molecules in the… CONTINUE READING

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