Hepsin cooperates with MYC in the progression of adenocarcinoma in a prostate cancer mouse model.

@article{Nandana2010HepsinCW,
  title={Hepsin cooperates with MYC in the progression of adenocarcinoma in a prostate cancer mouse model.},
  author={Srinivas R Nandana and Katharine Ellwood-Yen and Charles L Sawyers and Marcia Wills and Brandy Weidow and Thomas Case and Valeri Vasioukhin and Robert J. Matusik},
  journal={The Prostate},
  year={2010},
  volume={70 6},
  pages={591-600}
}
BACKGROUND Hepsin is a cell surface protease that is over-expressed in more than 90% of human prostate cancer cases. The previously developed Probasin-hepsin/Large Probasin-T antigen (PB-hepsin/LPB-Tag) bigenic mouse model of prostate cancer demonstrates that hepsin promotes primary tumors that are a mixture of adenocarcinoma and neuroendocrine (NE) lesions, and metastases that are NE in nature. However, since the majority of human prostate tumors are adenocarcinomas, the contribution of hepsin… CONTINUE READING