Hepsin, a cell surface serine protease identified in hepatoma cells, is overexpressed in ovarian cancer.

@article{Tanimoto1997HepsinAC,
  title={Hepsin, a cell surface serine protease identified in hepatoma cells, is overexpressed in ovarian cancer.},
  author={Hirotoshi Tanimoto and Yan Yan and Jane Clarke and Soheila Korourian and Kazushi Shigemasa and Tim H Parmley and Groesbeck Parham and Timothy J O'brien},
  journal={Cancer research},
  year={1997},
  volume={57 14},
  pages={2884-7}
}
Extracellular proteases mediate the digestion of neighboring extracellular matrix components in initial tumor growth, allow shedding or desquamation of tumor cells into the surrounding environment, provide the basis for invasion of basement membranes in target metastatic organs, and are required for release and activation of many growth and angiogenic factors. We identified overexpression of the serine protease hepsin gene in ovarian carcinomas and investigated the expression of this gene in 44… CONTINUE READING
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